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Technology

Next‑Generation CAR T

CAR T
Immunotherapy Innovation

At Atara, we are bringing together core technologies and capabilities to develop next-generation off-the-shelf chimeric antigen receptor T-cell (CAR T) immunotherapies. We are also collaborating with academic leaders and leveraging our world-class T-cell manufacturing and research expertise with the goal of rapidly advancing our CAR T programs.
Though the current generation of autologous CAR T immunotherapies, which utilize cells obtained from the patient, have transformed outcomes for B-cell malignancies, we believe many opportunities still exist to improve outcomes and address areas of high unmet need, including solid tumors and B-cell malignancies.

Aiming to Address Current CAR T Platform Limitations

Aiming to Address Current CAR T Platform Limitations

Potential Advantages of EBV-T‑Cells as Off-the-Shelf, Allogeneic T-cell Immunotherapy Platform

Potential Advantages of EBV-T‑Cells as Off-the-Shelf, Allogeneic T-cell Immunotherapy Platform

Potential Advantages of EBV-T‑Cells as Off-the-Shelf, Allogeneic T-cell Immunotherapy Platform
(1) Maeda Y, et al. Science. 2014 Dec 19;346(6216):1536-40; Regulatory T‑Cells (Tregs) “silence” T‑Cells with reactivity to self (2) Chapuis AG, et al. Nat Med. 2019 Jul;25(7):1064-1072. (3) Rosato P, et al. Nature Communications 2019 Feb 4; 10:567; Virus-specific memory T‑Cells populate tumors and can be repurposed for tumor immunotherapy. (4) Prockop S, et al. Proc ASCO 2016.

CAR T Pipeline

Our pipeline is rapidly expanding with novel technologies and next-generation, multi-targeted CAR T immunotherapies thanks to our collaborations with Moffitt Cancer Center and Memorial Sloan Kettering Cancer Center. VIEW CAR T PIPELINE

Collaborations

We seek to broaden the potential applications of our proprietary technology platform and explore new ways to help effectively bring transformational therapies to patients.
Publications

Developing Investigational T-cell Immunotherapies Based on Clinical Research

A collection of publications and presentations cover various areas of interest.

Developing Investigational T-cell Immunotherapies Based on Clinical Research